Background: Clinical criteria are important for improving diagnostic accuracy and ensuring comparability of patient cohorts in research studies. Objective: The aim was to assess the National Institute on Aging and Alzheimer's Association (NIA-AA) criteria for Alzheimer's disease (AD) dementia in AD and frontotemporal lobar degeneration (FTLD). Methods: Two hundred twelve consecutive patients with pathologically confirmed AD or FTLD who were clinically assessed in a specialist cognitive unit were identified. Fifty-five patients were excluded predominantly because of insufficient clinical information. Anonymized clinical data were rated against the NIA-AA criteria by raters who were blinded to clinical and pathologic diagnosis. Results: The NIA-AA AD dementia criteria had a sensitivity of 65.6% for probable and 79.5% for possible AD and a specificity of 95.2% and 94.0% for probable and possible, respectively. Conclusion: In patients with FTLD and predominantly early-onset AD, the NIA-AA AD dementia criteria have high specificity but lower sensitivity. The high specificity is due to the broad exclusion criteria.
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Harris, J. M., Thompson, J. C., Gall, C., Richardson, A. M. T., Neary, D., Du Plessis, D., … Jones, M. (2015). Do NIA-AA criteria distinguish Alzheimer’s disease from frontotemporal dementia? Alzheimer’s and Dementia, 11(2), 207–215. https://doi.org/10.1016/j.jalz.2014.04.516
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