Modeling in Respiratory Movement Using LabVIEW and Simulink

Abstract

Tricyclic analogs of melatonin with alkyl and cycloalkyl moieties in the [beta] position of the ethylamido chain have been prepared and tested for their ability to activate pigment granule aggregation in Xenopus laevis melanophores. The introduction of two methyl groups in the [beta] position of the side-chain of the methoxyl-substituted ligands induces a synergistic effect in agonist potency, which, importantly, is maintained after the methoxyl substituent is removed. The presence of more bulky [beta]-substituents, regardless of the size of the R group, seems to lead to antagonism.