Pro-survival signaling via CD27 costimulation drives effective CAR T-cell therapy

Abstract

The impact of CD27 costimulation on human T lymphocyte effector function and memory formation has been limited to evaluations using in vitro cell culture systems and observations from the clinic. We therefore investigated whether CD27 signaling augments antigen redirected human T-cell survival, expansion and function in vitro and in vivo. © 2012 Landes Bioscience.