A series of potential biologically active 2-[3-(4-phenyl-1-piperazinyl) propyl]-3-(4-substituted-benzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxides was synthesized in a straightforward manner by condensation of respective 3-substituted-4-hydroxy-1,2-benzothiazine 1,1-dioxides with 1-(1-chloropropyl)- 4-phenylpiperazine. The structures of all of the newly formed compounds were identified by elemental analysis, FTIR and 1 H NMR. The synthesized compounds were subjected to preliminary evaluation using differential scanning calorimetry (DSC) to determine the existence of multiple crystal forms. The DSC scans for all compounds show more than one endothermic effect, which might suggest dynamic proton transfer between two or three possible tautomeric forms: O-keto/O-enol, O-enol/O-keto and O-keto/O-keto/CH 2 in crystals 2-[3-(4-phenyl-1-piperazinyl)propyl]-3-(4-substituted-benzoyl)-4-hydroxy-2H-1, 2-benzothiazine 1,1-dioxides. © 2013 The Author(s).
CITATION STYLE
Krzyżak, E., Szczȩåniak-Siȩga, B., & Malinka, W. (2014). Synthesis and thermal behaviour of new benzo-1,2-thiazine long-chain aryl-piperazine derivatives. Journal of Thermal Analysis and Calorimetry, 115(1), 793–802. https://doi.org/10.1007/s10973-013-3185-1
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