Cardiovascular effects induced by linalool in normotensive and hypertensive rats

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Abstract

Linalool is a monoterpene alcohol and constituent of several Brazilian aromatic medicinal plants, popularly used against hypertension. Cardiovascular effects induced by linalool were evaluated. In normotensive rats, (±)-linalool [1, 5, 10, and 20 mg/kg body weight (BW); intravenous (i.v.)]-induced hypotension was associated with tachycardia, which was attenuated by atropine (2 mg/kg BW) and NG-nitro-L-arginine methyl ester (20 mg/kg BW), but was not modified after indomethacin (5 mg/kg BW) administration. In hypertensive rats, linalool [200 mg/kg BW; oral (v.o.)] reduced blood pressure without changing the heart rate. In intact rings of rat mesenteric artery precontracted with 10 μM phenylephrine, linalool (from 6.4 · 10-6 to 6.4 · 10-3 M) induced relaxations in a concentration-dependent manner [Emax = (115 ± 13)%] that were not changed after atropine administration [Emax = (105 ± 2)%], and were not different from those obtained in endothelium-denuded rings precontracted with phenylephrine [Emax = (108 ± 7)%] or 80 mM KCl [Emax = (113 ± 7)%] or tetraethylammonium incubation [Emax = (105 ± 12)%]. Linalool (1.9 · 10-3 M) antagonized the contractions induced by CaCl2 (3 · 10-6 - 10-2 M) (maximal inhibition, 81%). Furthermore, linalool inhibited the contractions induced by 10 μM phenylephrine or 20 mM caffeine. In conclusion, these results demonstrate that linalool reduces blood pressure probably due to a direct effect on the vascular smooth muscle leading to vasodilation. © 2013 Verlag der Zeitschrift für Naturforschung, Tübingen.

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Anjos, P. J. C., Lima, A. O., Cunha, P. S., De Sousa, D. P., Onofre, A. S. C., Ribeiro, T. P., … Santos, M. R. V. (2013). Cardiovascular effects induced by linalool in normotensive and hypertensive rats. Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, 68 C(5–6), 181–190. https://doi.org/10.1515/znc-2013-5-603

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