Host defense peptides (HDPs) are relatively small, mostly cationic, amphipathic, and of variable length, sequence, and structure. The majority of these peptides exhibit broad-spectrum antimicrobial activity and often activity against viruses and some cancer cell lines. In addition, HDPs also provide a range of immunomodulatory activities related to innate immunity defense, inflammation, and wound healing. The development of these multi-faceted molecules and their bioactivities into clinically important therapeutics is being pursued using a number of different approaches. Here we review the role of HDPs in nature and application of this role to the development of novel therapeutics.
CITATION STYLE
Zhang, L., & Falla, T. J. (2010). Potential Therapeutic Application of Host Defense Peptides. In Methods in Molecular Biology (Vol. 618, pp. 303–327). Humana Press Inc. https://doi.org/10.1007/978-1-60761-594-1_19
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