GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects

Abstract

Introduction: Lesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system. Material and methods: We have evaluated the linkage disequilibrium patterns and haplotype frequencies of GABRG1 and GABRA2 genes in 133 alcoholics divided according to Lesch's typology and in 145 matched controls. Results: Besides several relationships at a threshold of statistical significance, we found no significant differences in the haplotype distribution of these genes between alcoholics and controls. Conclusions: Lesch's typology may not be related with the genotype of alcoholics - at least in terms of genes with an established role in the development of dependency. Copyright © 2012 Termedia & Banach.