Novel monoterpene lactones from Cinnamomum inunctum

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Abstract

Four new monoterpene lactones, 5-(2,3-dihydroxy-3-methylbutyl)-4-hydroxy-4-methyldihydrofuran-2(3H)-one (1), 5-(2,3-dihydroxy-3-methylbutyl)-4-methylfuran-2(5H)-one (2), 8-hydroxy-4,7,7-trimethyl-1,6-dioxaspiro[4.4]non-3-en-2-one (3) and 8-hydroxy-4,7,7-trimethyl-1,6-dioxaspiro[4.4]non-3-en-2-one (4), were isolated from the methanolic extract of the fruit of Cinnamomum inunctum, a folk medicine in Myanmar, together with a known compound, 3-hydroxy-4,4-dimethyl-4-butyrolactone (5). Their chemical structures were determined by spectral methods. Among these, 3 and 4 possessed unique spirolactone moieties.

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Fuchino, H., Yazawa, A., Kiuchi, F., Kawahara, N., Takahashi, Y., & Satake, M. (2015). Novel monoterpene lactones from Cinnamomum inunctum. Chemical and Pharmaceutical Bulletin, 63(10), 833–836. https://doi.org/10.1248/cpb.c15-00368

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