Nonsinusoidal neuronal oscillations: Bug or feature?

Abstract

There is compiling evidence suggesting that independent neuronal ensembles are coordinated in time and space through cross-frequency coupling (CFC). However, recent studies have convincingly demonstrated that nonsinusoidal oscillations produce serious biases in state of the art CFC metrics. Although most of studies treat nonsinusoidal waves as a nuisance or just ignore them, fortunately some scientists are starting to exploit their neurophysiological relevance opening new research vistas with critical implications.