We examined the relationship between CSF immune cells and neurocognition and neuronal damage in HIV+ individuals before and after initiating antiretroviral therapy. Multivariate analysis at baseline indicated that greater CD4+ T cell abundance was associated with better cognition (p =.017), while higher CSF HIV RNA was associated with increased neuronal damage (p =.014). Following 24 weeks of antiretroviral therapy, CD8+ T cells, HLA-DR expressing CD4+ and CD8+ T cells, B cells, NK cells, and non-classical monocyte percentage decreased in CSF. Female gender was negatively associated with cognitive performance over time, as was higher percentage of HLA-DR expressing CD8+ T cells at baseline.
CITATION STYLE
Amundson, B., Lai, L., Mulligan, M. J., Xu, Y., Zheng, Z., Kundu, S., … Anderson, A. M. (2020). Distinct cellular immune properties in cerebrospinal fluid are associated with cognition in HIV-infected individuals initiating antiretroviral therapy. Journal of Neuroimmunology, 344. https://doi.org/10.1016/j.jneuroim.2020.577246
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