Taking the development of inhibitors for the tRNA-modifying enzyme tRNA-guanine transglycosylase (TGT) as an example, the scope of a structure-based drug development project will be demonstrated, performed via several cycles of iterative design. The described example is based on studies, performed at ETH-Zurich and University of Marburg in joint collaboration. As these studies have been executed in an academic environment, different tools of structure-based design have been applied and several issues of more fundamental interest to the methodological background of the project could be addressed. © Springer Science + Business Media B.V. 2009.
CITATION STYLE
Klebe, G. (2009). Structure-based design of tRNA-guanine transglycosylase inhibitors. In NATO Science for Peace and Security Series A: Chemistry and Biology (pp. 103–120). Springer Verlag. https://doi.org/10.1007/978-90-481-2339-1_7
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