Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils

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Abstract

Helicobacter pylor is associated with an inflammatory reaction in the stomach and duodenum, yet the mechanism of this inflammatory infiltrate is unknown. The ability of Helicobacter pylon to secrete a factor that attracts leucocytes is investigated. Helicobacterpylori conditioned supernatant attracted neutrophils and monocytes with 50-100% of the activity of control chemotactic factor, 10-8M formyl-methionine-leucine-phenylalanine. Strains derived from individuals with ulcer or non-ulcer associated H pylori infections displayed similar chemotactic activity. Preliminary characterisation shows that the factor has a molecular weight of less than 3000, is heat stable, is acid resistant, and can be diluted at least 10-fold. Checkerboard analysis confirmed that the activity was chemotactic rather than chemokinetic. This chemotactic activity could play a role in the pathogenesis of Helicobacter pylori gastritis.

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Craig, P. M., Territo, M. C., Karnes, W. E., & Walsh, J. H. (1992). Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils. Gut, 33(8), 1020–1023. https://doi.org/10.1136/gut.33.8.1020

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