We report a route to synthesize a wide range of organophosphates of biological significance in a deep eutectic solvent (2:1 urea and choline chloride), utilizing various orthophosphate sources. Heating an organic alcohol in the solvent along with a soluble phosphorus source yields phosphorus esters of choline as well as that of the added organic in yields between 15 to 99 %. In addition, phosphite analogs of biological phosphates and peptides were also formed by the simple mixing of reagents and heating at 60-70 C in the deep eutectic solvent. The presented dehydration reactions are relevant to prebiotic and green chemistry in alternative solvents. © 2013 Springer Science+Business Media New York.
CITATION STYLE
Gull, M., Zhou, M., Fernández, F. M., & Pasek, M. A. (2014). Prebiotic phosphate ester syntheses in a deep eutectic solvent. Journal of Molecular Evolution, 78(2), 109–117. https://doi.org/10.1007/s00239-013-9605-9
Mendeley helps you to discover research relevant for your work.