Flexible Hydrophobic CFP@PDA@AuNPs Stripes for Highly Sensitive SERS Detection of Methylene Blue Residue

Abstract

Considering the inherent hydrophilic and porous nature of paper, the rapid absorption and diffusion of aqueous analyte solutions on paper-based SERS substrates may severely affect the Raman detection sensitivity and accuracy in the detection of target molecules. In this work, a series of hydrophobic CFP@PDA@AuNPs stripes were obtained through in situ synthesizing of gold nanoparticles (AuNPs) on a polydopamine (PDA)-decorated cellulose filter paper (CFP) and functionalized with perfluorodecanethiol (PFDT). When the SERS performance of the substrates was examined using 4-ATP, the hydrophobic CFP@PDA@AuNPs substrate showed superior sensitivity, reproducibility and stability due to the hydrophobic enrichment effect, with the detection limit decreasing to 10−9 M and the enhancement factor as high as 2.55 × 107. More importantly, it was feasible to apply the hydrophobic paper substrate as an excellent SERS sensor to detect methylene blue (MB) residues in lake water in a highly sensitive manner. The lowest detectable limit of MB was 100 nM, and it showed a low relatively standard deviation (RSD) value of 5.28%. Hydrophobic CFP@PDA@AuNPs stripes may serve as excellent sensors for target molecule detection and have tremendous potential in food security, and environmental and chemical detection.