Optical resolution by crystallization from melt using enantiomer derivatives as resolving agents: Nonlinear behavior of resolving agent mixtures

Abstract

Substituted racemic 1-phenylethylamine derivatives were reacted in molten phase with chiral N-substituted 1-phenylethylamine dicarboxylic acid derivatives (4-9), and their mixtures (e.g., 4+6, 7+8, etc.) in different ratios, and the crystalline quasi-racemic diastereomers so formed were separated. Nonlinear behavior of the mixtures of resolving agents having related structure and considerable positive and negative chiral-chiral interactions were observed. © 2005 Wiley-Liss, Inc.