Diversity-oriented enantioselective synthesis of highly functionalized cyclic and bicyclic alcohols

Abstract

The copper-catalyzed hetero-allylic asymmetric alkylation (h-AAA) of functionalized Grignard reagents that contain alkene or alkyne moieties has been achieved with excellent regio- and enantioselectivity. The corresponding alkylation products were further transformed into a variety of highly functionalized cyclic and bicyclic alcohols with excellent control over the chemo-, regio-, and stereoselectivity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.