Features of hodgkin-huxley neuron response to periodic spike-train inputs

Abstract

Researches on neuron response to external stimulation will provide useful insights into neural mechanism of learning and cognitive function of the brain. In this article, a neuron described by Hodgkin-Huxley model receives periodic spike-train inputs. The responses to inputs with various frequencies and synaptic conductivities are simulated. The results show that mode-locking response pattern is the main type of response to periodic inputs, which is consistent with general knowledge. The mode-locking patterns as the function of the frequency and synaptic conductivity are given and characteristics of mode-locking boundaries are analyzed. Furthermore, how input frequency and synaptic conductivity influence HH neuron response is in detail explained respectively. © 2009 Springer Berlin Heidelberg.