Targeting the insulin-like growth factor network in cancer therapy

70Citations
Citations of this article
53Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

During the last decades, changes in the insulin-like growth factor (IGF) signaling have been related to the pathogenesis of cancer. Therefore, IGFs became highly attractive therapeutic cancer targets. Several drugs including monoclonal antibodies (mAbs), small molecule tyrosine kinase inhibitors (RTKIs), antisense oligonucleotids (ASOs) and IGF-binding proteins (IGFBPs) targeting the IGF axis were developed. With over 60 ongoing clinical trials, the IGF1 receptor (IGF1R) is currently one of the most studied molecular targets in the field of oncology. In this review, we provide an overview on the IGF axis, its signaling pathways and its significance in neoplasia. We critically review the preclinical and clinical studies investigating the role of IGF1R as a cancer target and discuss preliminary results and possible limitations. © 2011 Landes Bioscience.

Cite

CITATION STYLE

APA

Heidegger, I., Pircher, A., Klocker, H., & Massoner, P. (2011, April 15). Targeting the insulin-like growth factor network in cancer therapy. Cancer Biology and Therapy. https://doi.org/10.4161/cbt.11.8.14689

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free