One-Pot asymmetric nitro-mannich/hydroamination cascades for the synthesis of pyrrolidine derivatives: Combining organocatalysis and gold catalysis

Abstract

The highly enantioselective preparation of trisubstituted pyrrolidine derivatives employing a one-pot nitro-Mannich/hydroamination cascade is reported. This cascade approach utilizes an asymmetric bifunctional organocatalytic nitro-Mannich reaction followed by a gold-catalyzed allene hydroamination reaction. The products are afforded in good yields and excellent diastereo- and enantioselectivities. © 2014 American Chemical Society.