1022 Association Between Homocysteine and Sleep in Postmenopausal Women

Abstract

Introduction: Homocysteine (Hcy) is a sulfur amino acid, considered an independent risk factor for cardiovascular disease. Excessive Hcy directly harms the endothelium and can lead to premature atherosclerosis, with progression to stroke and acute myocardial infarction. One of the causes of hyperhomocysteinemia (Hhcy) is known to be hypoestrogenism. Hypoestrogenism increases the cardiovascular risk as well as the occurrence of sleep disorders. Hhcy prevalence varies by population and its value in postmenopausal women in Brazil is unknown. Objective: To evaluate the prevalence of hyperhomocysteinemia in postmenopausal women in the city of São Paulo. Check if there is an association between the variables: Hcy and lipid profile; Hcy and hot flushes; Hcy and subjective sleep parameters Methods: A population-based cross-sectional study was conducted that included a total of 1,042 volunteers living in the city of São Paulo in 2007. This research is part of the São Paulo Sleep Epidemiological Study (EPISONO). Study approved by the Ethics Committee (CEP # 0593/06) and registered with ClinicalTrials. gov (NCT00596713). Hcy, total cholesterol, HDL, LDL, triglycerides were measured. Sleep questionnaires PSQI, IGI, Epworth Sleepiness Scale were used. The GLzM (Generalized Linear Model) was used to verify the association between the different variables. Dependent variables were used in binominal and gama distribution when needed Results: The sample consisted of 193 postmenopausal women, with a mean age of 58 years (SD ± 9). The prevalence of Hhcy in this sample was 4.7%, while 14.7% had dyslipidemia 22.8% with hypertriglyceridemia and 29% with low HDL levels. There was an association between Hcy and HDL. There was no association between Hcy and hot flushes, Hcy and LDL, nor with Hcy and sleep parameters. Conclusion: The studied population presented low prevalence of Hhcy and there was no association between Hcy and sleep parameters.