The wide application of pyrethroids has led to the rapid development of insecticide resistance in mosquitoes, leading to a rise in mosquito-borne diseases. We previously identified five differentially expressed lipase family genes upon evaluating the transcriptomes of deltamethrin-resistant and deltamethrin-susceptible strains of Culex pipiens pallens. Herein, the gene expression levels were verified by quantitative real-time PCR, and two lipase family genes, lipase A and pancreatic triacylglycerol lipase A, were chosen for further investigations. Using cell viability assays and Centers for Disease Control and Prevention bottle bioassays, lipase A was found to increase the resistance of mosquitoes against deltamethrin both in vitro and in vivo. Our findings indicate that lipase A is involved in conferring deltamethrin resistance in Cx. pipiens pallens.
CITATION STYLE
Hu, H. X., Zhou, D., Ma, L., Shen, B., Sun, Y., & Zhu, C. L. (2020). Lipase is associated with deltamethrin resistance in Culex pipiens pallens. Parasitology Research, 119(1), 23–30. https://doi.org/10.1007/s00436-019-06489-2
Mendeley helps you to discover research relevant for your work.