MALDI-MSI has been demonstrated to be a suitable technique in pharmaceutical research for providing information of the distribution of low molecular weight compounds such as drugs and their metabolites within whole-body tissue sections. Important ADME information can be determined by MALDI-MSI analysis of the distribution of drugs and metabolites in whole-body tissue sections taken from animals killed at a range of time points postdose. In this example we applied MALDI-MSI to the localization of a compound and its primary metabolite in whole-body mouse sections. © 2010 Springer Science+Business Media, LLC.
CITATION STYLE
Prideaux, B., Staab, D., & Stoeckli, M. (2010). Applications of MALDI-MSI to pharmaceutical research. Methods in Molecular Biology. https://doi.org/10.1007/978-1-60761-746-4_23
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