Luminescent Anion Sensing by Transition-Metal Dipyridylbenzene Complexes Incorporated into Acyclic, Macrocyclic and Interlocked Hosts

Abstract

A series of novel acyclic, macrocyclic and mechanically interlocked luminescent anion sensors have been prepared by incorporation of the isophthalamide motif into dipyridylbenzene to obtain cyclometallated complexes of platinum(II) and ruthenium(II). Both the acyclic and macrocyclic derivatives 7⋅Pt, 7⋅Ru⋅PF6, 10⋅Pt and 10⋅Ru⋅PF6 are effective sensors for a range of halides and oxoanions. The near-infra red emitting ruthenium congeners exhibited an increased binding strength compared to platinum due to the cationic charge and thus additional electrostatic interactions. Intramolecular hydrogen-bonding between the dipyridylbenzene ligand and the amide carbonyls increases the preorganisation of both acyclic and macrocyclic metal derivatives resulting in no discernible macrocyclic effect. Interlocked analogues were also prepared, and preliminary luminescent chloride anion spectrometric titrations with 12⋅Ru⋅(PF6)2 demonstrate a marked increase in halide binding affinity due to the complementary chloride binding pocket of the [2]rotaxane. 1H NMR binding titrations indicate the interlocked dicationic receptor is capable of chloride recognition even in competitive 30 % aqueous mixtures.