Thiazolidinediones (TZDs) enhance insulin secretory response via GPR40 and adenylate cyclase (AC)

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Abstract

Thiazolidinediones are synthetic PPARγ ligands that enhance insulin sensitivity, and that could increase insulin secretion from β-cells. However, the functional role and mechanism(s) of action in pancreatic β-cells have not been investigated in detail.

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Hwang, M., Kim, H. S., Jin, S. M., Hur, K. Y., Kim, J. H., & Lee, M. K. (2021). Thiazolidinediones (TZDs) enhance insulin secretory response via GPR40 and adenylate cyclase (AC). Journal of Cellular Physiology, 236(12), 8137–8147. https://doi.org/10.1002/jcp.30467

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