Influence of addition of [2-(methacryloyloxy)ethyl] trimethylammonium chloride to an experimental adhesive

Abstract

The aim of this study was to develop an experimental adhesivewith addition of [2-(methacryloyloxy)ethyl]trimethylammoniumchloride (METAC) and to evaluate its mechanical and biologicalproperties and its in vitro antibacterial activity. An experimentaladhesive resin was formulated with Bis-GMA, TEGDMA, andHEMA. The antibacterial monomer was added at concentrations of1%, 2.5%, and 5% (METAC groups). A group without METAC additionwas used as control. The experimental adhesives were evaluated asto their antibacterial potential against Streptococcus mutans, degreeof conversion, and softening in ethanol for 2 hours. The data wereanalyzed by one-way ANOVA, Tukey’s post-hoc test, and the pairedStudent’s t-test (significance level of 0.05). METAC showed antibacterialactivity against S. mutans at all concentrations (p < 0.05). There was nostatistical difference across METAC groups (p > 0.05). The 1%, 2.5%, and5% groups yielded the highest mean values for degree of conversion(p < 0.05). The 1% group did not differ from the control group (p > 0.05).There was no statistical difference in baseline microhardness values(p > 0.05) and microhardness values after immersion in ethanol werelower than at baseline for all groups (p < 0.05). There was no statisticaldifference in the reduction of Knoop hardness number (KHN) afterimmersion in ethanol for any of the groups (p > 0.05). The results of thepresent study indicate that METAC is a promising antibacterial agentwhen added to an adhesive system