Genetic role of HLA-G14 base pair indel polymorphic gene with type 1 diabetic patients

Abstract

The prevalence of Diabetic mellitus in Iraq is high for both males and females, according to the World Health Organization (WHO). The major histocompatibility complex (MHC)/HLA region on chromosome 6p21 has been shown to contain the major genetic component of Type1Diabetic mellitus. A 14-base pair polymorphism inserts and/or removal in exon-8 has a potential role in HLA. This research explores the role of 14-bp HLA-G insertion / deletion polymorphism in Type 1 Diabetes mellitus (T1DM) patients. The polymorphism allele frequency was calculated in patients with T1DM and control. Insertion allele (70.8%) and homozygous deletion genotype are associated with T1D susceptibility (51.6%), while control group (38.3%) and heterozygous genotype of the 14-bp indel are correlated with T1D defense (38.3%) and control group (50%). also a significant differences in the allele frequencies of the HLA-G 14-bp polymorphism were observed. This research shows a sturdy relation among polymorphism HLA-G 14-bp and type1D.M. (P = 0.009). Our findings describe the combination of the 14-base pair insertion allele and the homozygous genotype deletion to the progress of T1D.