Application feasibility of antioxidant activity evaluation using potentiometry in major depressive disorder

Abstract

Potentiometry utilizing redox reactions in a [Fe(CN)6]3 -/[Fe(CN)6]4- redox-reagent solution has been considered as simple, highly sensitive, fast, and inexpensive method for evaluating total antioxidant activity (TAA) in various samples such as drinks, food, blood, etc. In this study, for the first time, the determination of TAA using potentiometric method has been applied to depression rating. For a depressed group of 94 persons and a normal group of 66 persons, beck depression inventory (BDI) score and TAA value were evaluated. From a comparison of BDI and TAA results, it is found that the TAA value is closely related to the BDI score and the value of TAA increases with decreasing BDI score. The plot of TAA vs. BDI exhibited a linear relationship with a negative correlation (Pearson's coefficient r = -0.318, P < 0.01). This strongly suggests that the potentiometric method for TAA determination has a potential to be used as a clinical tool in depression. © 2014 The Electrochemical Society of Japan.