Post-taskmodulation of resting state eeg differentiates mci patients from controls

Abstract

Background: Early identification of cognitive decline is critical for identifying individuals for inclusion in clinical trials and for eventual care planning. Methods: A sample (ages 60–90 years) of consensus-diagnosed, community-dwelling Blacks (61 cognitively typical [HC], 28 amnestic mild cognitive impairment [aMCI], and 14 nonamnestic MCI [naMCI]) were recruited from theMichigan Alzheimer’s Disease Research Center and the Wayne State University Institute of Gerontology. Participants received two resting state electroencephalograms (rsEEG, eyes closed) between which they engaged in a visual motion direction discrimination task. rsEEG %change current source densities across all frequency bands and regions of interest were calculated. Results: EEG current density was not different across groups for pre-task resting state. However, compared toHC, aMCI showed significantly greater declines at temporal and central cortical sites, while naMCI showed significant parietal declines. Conclusion: This novel approach of post–pre/cognitive challenge rsEEG successfully discriminated older persons with MCI from those without was sensitive to cognitive decline.