Discovery and current status of evaluation system of bioavailability and related pharmaceutical technologies for traditional Chinese medicines—flos lonicerae Japonicae—fructus forsythiae herb couples as an example

Abstract

Traditional Chinese medicines (TCMs) have attracted extensive interest throughout the [world due to their long history of health protection and disease control, and the internalization [of TCM preparations or patented drugs has been considered a wind vane in the process of TCM [modernization. However, multi-target effects, caused by multiple components in TCMs, hinder [not only the construction of the quality evaluation system (bioavailability), but also the application [of pharmaceutical technologies, which results in the poor efficacy in clinical practice. This review [describes the methods in the literature as well as in our thoughts about how to identify the marker [components, establish the evaluation system of bioavailability, and improve the bioavailability in [TCM preparations. We expect that the current study will be positive and informative.