The relationship between virus load response to highly active antiretroviral therapy and change in CD4 cell counts: A report from the Women's Interagency HIV Study

20Citations
Citations of this article
12Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The relationship between the pattern of virus load response to highly active antiretroviral therapy (HAART) and CD4 lymphocyte response was assessed in a cohort of 249 human immunodeficiency virus (HIV) type 1-infected women at 3 times: 1 before and 2 after initiation of therapy, with follow-up of 6-12 months. Patients with a durable response to HAART (i.e., >1 log decrease in HIV-1 RNA sustained for the study periods) had a continuous and significant increase in CD4 cell counts over time, whereas those with no response (<0.5 log decrease in HIV-1 RNA) had a slight decline. Patients with a mixed response (initial decrease >1 log, followed by a subsequent decrease <0.5 log) had an increase in CD4 cell count, followed by a plateau. The trend in CD4 cell count differed significantly by response to HAART, with those patients who experienced a durable response having significantly higher CD4 cell counts than others.

References Powered by Scopus

Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy

1764Citations
N/AReaders
Get full text

Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults

979Citations
N/AReaders
Get full text

Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: A prospective cohort study

883Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Antiretroviral treatment for adult HIV infection in 2002: Updated recommendations of the International AIDS Society-USA Panel

715Citations
N/AReaders
Get full text

Late presenters in the era of highly active antiretroviral therapy: Uptake of and responses to antiretroviral therapy

198Citations
N/AReaders
Get full text

Predictors of long-term increase in CD4<sup>+</sup>cell counts in human immunodeficiency virus - Infected patients receiving a protease inhibitor - Containing antiretroviral regimen

111Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

DeHovitz, J. A., Kovacs, A., Feldman, J. G., Anastos, K., Young, M., Cohen, M., … Greenblatt, R. M. (2000). The relationship between virus load response to highly active antiretroviral therapy and change in CD4 cell counts: A report from the Women’s Interagency HIV Study. Journal of Infectious Diseases, 182(5), 1527–1530. https://doi.org/10.1086/315875

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 7

64%

Researcher 3

27%

Professor / Associate Prof. 1

9%

Readers' Discipline

Tooltip

Medicine and Dentistry 5

45%

Agricultural and Biological Sciences 4

36%

Social Sciences 1

9%

Sports and Recreations 1

9%

Save time finding and organizing research with Mendeley

Sign up for free