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Background: The effects of baseline and changes in blood pressure and low density lipoprotein (LDL) cholesterol on the carotid intima media thickness (IMT) have not been well documented.Methods: A total of 2572 adults (mean age 53.8 years, 54.6% women) in a Taiwanese community undertook three blood pressure and LDL cholesterol examinations over 6 years. Latent growth curve modeling was used to investigate the effects of baseline and change in blood pressure and LDL cholesterol on IMT.Results: Greater baseline LDL and blood pressure were associated with an increase in IMT (0.005 ± 0.002 mm per 1 mg/dL [p = 0.006] and 0.041 ± 0.004 mm mmHg [p <0.0001], respectively. Change in blood pressure was associated with a significant increase in IMT (0.047±0.016, P = 0.004), whilst the association between change in LDL and change in IMT was not statistically significant (0.008±0.006, P = 0.20).Conclusions: Carotid IMT was associated with baseline blood pressure and LDL cholesterol, yet only changes of blood pressure, not LDL cholesterol, were related to carotid IMT during the 6-year observation. © 2012 Chien et al.; licensee BioMed Central Ltd.
Chien, K. L., Tu, Y. K., Hsu, H. C., Su, T. C., Lin, H. J., Chen, M. F., & Lee, Y. T. (2012). Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis. BMC Cardiovascular Disorders, 12. https://doi.org/10.1186/1471-2261-12-66