Biochemical effect of ezetimibe/ simvastatin and ginger root extract on hyperlipidemia and diabetes mellitus induced experimentally in rats

Abstract

The present study was aimed to explore the biochemical effect Ezetimibe/ Simvastatin and Ginger in hyperlipidemic and diabetic male albino rats induced by feeding rats high-fat diet for 4-weeks with intraperitoneal injection of a single low dose of streptozotocin (50 mg/kg) to explore the glycemic condition, lipids and lipoproteins profile, hormones, oxidative stress and antioxidant status. Sixty male albino rats were divided into four groups (15 rats each). Group I: Normal control rats fed on normal ration, received no drugs. Group II: Hyperlipidemic and Diabetic rats, received no drugs and act as + ve control .Group III: Hyperlipidemic and Diabetic rats treated with Ezetimibe/Simvastatin at a dose of 1.8 mg/kg/b.w/day orally for 4 weeks. Group IV: Hyperlipidemic and Diabetic rats treated with ginger root aqueous extract at a dose of 400 mg/kg/b.w/day orally for 4 weeks. The obtained results revealed that hyperlipidemic and diabetic rats showing highly significant increase in plasma glucose level, Total cholesterol (TC), Triacylglycerol (TG), Low-density lipoproteins (LDL-C), Very low density lipoprotein (VLDL-C), insulin, insulin resistance (IR), insulin receptor, leptin and L-Malondialdehyde, (L-MDA). On the other hand, plasma High-density lipoprotein-cholesterol (HDL-C) and Total antioxidant capacity (TAC) were showed a different behavioral pattern, where it was detectably significant decrease. Treatment with Ezetimibe/Simvastatin and administration of ginger root extract improved glucose levels, oxidative stress, and insulin resistance and exert antioxidant properties beside its anti-hyperlipidemic activity.