Abstract
The somatic hot spot mutation STAT5BN642H was found in many T cell leukemia/lymphoma patients. We generated and analyzed a transgenic mouse model with hematopoietic STAT5BN642H expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and its relevance for pre-clinical studies.
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Pham, H. T. T., Hengstschläger, M., & Moriggl, R. (2018). A haunted beast: Targeting STAT5BN642H in T-Cell Neoplasia. Molecular and Cellular Oncology, 5(3). https://doi.org/10.1080/23723556.2018.1435181
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