A coupled finite element model of tumor growth and vascularization

Abstract

We present a model of solid tumor growth which can account for several stages of tumorigenesis, from the early avascular phase to the angiogenesis driven proliferation. The model combines several previously identified components in a consistent framework, including neoplastic tissue growth, blood and oxygen transport, and angiogenic sprouting. First experiments with the framework and comparisons with observations made on solid tumors in vivo illustrate the plausibility of the approach. Explanations of several experimental observations are naturally provided by the model. To the best of our knowledge this is the first report of a model coupling tumor growth and angiogenesis. © Springer-Verlag Berlin Heidelberg 2007.