Hydration patterns in sodium alginate polymeric matrix tablets-the result of drug substance incorporation

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Abstract

The purpose was to show, using destructive/nondestructive methods, that the interplay between water, tablet structure, and composition determine the unique spatiotemporal hydration pattern of polymer-based matrices. The tablets containing a 1:1 w/w mixture of sodium alginate with salicylic acid (ALG/SA) or sodium salicylate (ALG/SNA) were studied using Karl Fischer titration, differential scanning calorimetry, X-ray microtomography, and magnetic resonance imaging. As the principal results, matrix specific features were detected, e.g., “locking” of the internal part of the matrix (ALG/SA); existence of lamellar region associated with detection of free/freezing water (ALG/SA); existence of water penetrating the matrix forming specific region preceding infiltration layer (ALG/SNA); switch in the onset temperature of endothermic water peak associated with an increase in the fraction of non-freezing water weight per dry matrix weight in the infiltration layer (ALG/SNA). The existence of complicated spatiotemporal hydration patterns influenced by matrix composition and molecular properties of constituents has been demonstrated.

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APA

Juszczyk, E., Kulinowski, P., Baran, E., Birczyński, A., Klaja, J., Majda, D., … Dorożyński, P. (2021). Hydration patterns in sodium alginate polymeric matrix tablets-the result of drug substance incorporation. Materials, 14(21). https://doi.org/10.3390/ma14216531

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