Abstract
A model of cardiac microstructure and diffusion MRI is presented. The results show a good correspondence between the simulated and experimental measurements. A sensitivity analysis shows that the diffusivity has the greatest effect on both the apparent diffusion coefficient and the fractional anisotropy. The cross-sectional area of the cells is the next most important factor; the aspect ratio of the cell cross-section also affects the fractional anisotropy. Neither the cell length nor the volume fraction of cells has a marked effect.
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Bates, J., Teh, I., Kohl, P., Schneider, J. E., & Grau, V. (2015). Sensitivity analysis of diffusion tensor MRI in simulated rat myocardium. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 9126, pp. 120–128). Springer Verlag. https://doi.org/10.1007/978-3-319-20309-6_14
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