We have provocative data which suggest that the nuclear estrogen-receptor complex interacts with DNA, that this interaction is required for appropriate receptor turnover or processing, and that processing may be essential for induction of a specific protein by estrogen. If the receptor is improperly inserted into DNA, as for instance when it is bound by nafoxidine, processing fails and the biological effect is blunted.
CITATION STYLE
Horwitz, K. B., & McGuire, W. L. (1979). Estrogen control of progesterone receptor induction in human breast cancer: role of nuclear estrogen receptor. Advances in Experimental Medicine and Biology, 117, 95–110. https://doi.org/10.1007/978-1-4757-6589-2_5
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