C-H functionalization logic enables synthesis of (+)-hongoquercin A and related compounds

Abstract

The specifics: A synthesis of the sesquiterpenoid antibiotic (+)-hongoquercin A using sequential site-specific C-H methylation and oxidation reactions is described. A key advancement toward this goal was the development of a ligand-accelerated C-H methylation reaction, and enabled the generation of a library of eight structurally diverse analogues. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.