EFFECTS OF THYROID DYSFUNCTION ON LIPID PROFILE

Abstract

Background: Thyroid function regulates a wide array of metabolic parameters. Thyroid function significantly affects lipoprotein metabolism as well as some cardiovascular disease (CVD) risk factors, thus influencing overall CDV risk. Methods: A cross sectional study has been conducted to assess the association of subclinical hypothyroidism and overt hypothyroidism with lipid abnormalities. Results: Serum HDL cholesterol in group A was 37.97±7.97 mg/dl, that  in group B was 37.62±6.67 mg/dl, while in group C it was 36.27±5.79 mg/dl. Serum LDL cholesterol in group A was 150.9±29.70 mg/dl, that  in group B was 115.2±22.02 mg/dl, while in group C  it was 93.07±19.88 mg/dl. Serum total cholesterol in group A was 223±32.69 mg/dl, that in group B was 179.67±27.50 mg/dl, while in group C it was 152.4±21.47 mg/dl. Serum VLDL cholesterol in group A was 34.12±11.06 mg/dl, that in group B was 26.85±4.01 mg/dl, while in group C it was 23.05±3.09 mg/dl. Serum VLDL cholesterol in group A was 167.42±47.83 mg/dl, that in group B was 134.37±20.22 mg/dl, while in group C it was 115.17±15.66 mg/dl. Conclusion: Thyroid dysfunction can have an important effect on lipid profile. Biochemical screening for thyroid dysfunction is critical in all dyslipidemic patients, as well as in all patients with unexpected improvement or worsening of their lipid profile. Keywords: LDL,HDL,Cholesterol.