Cardiac electrophysiology model adjustment using the fusion of MR and optical imaging

Abstract

Despite important recent efforts in cardiac electrophysiology modelling, there is still a strong need for validating macroscopic models, that are well suited for diagnosis and treatment planning. In this paper we present a method to adjust the parameters of a macroscopic electrophysiology model on depolarisation and repolarisation maps obtained ex-vivo from optical imaging. With this imaging technique, optical fluorescence data are recorded with high spatial and temporal resolution on a large healthy porcine heart. A model of the myocardium is built from the MR images of the same heart, which also integrates the myocardial fibre orientation measured with DTI. We then present the first quantitative adjustment of a personalised volumetric model of the myocardium. © 2008 Springer-Verlag Berlin Heidelberg.