Assessing Epilepsy-Related Behavioral Phenotypes in Adult Zebrafish

Abstract

Over the past decades, zebra fi sh have been presented as a novel and valuable tool for modeling complex human diseases. Epilepsy is a serious brain disorder with multiple genetic and environmental causes. Our poor understanding of its pathogenesis requires novel paradigms and model organism for translational experimental epilepsy research. Seizure-like behavior has already been studied in both larval and adult zebra fi sh models, including genetically modi fi ed strains and convulsant drugs. This protocol describes how to quantify seizure-like behavioral phenotypes commonly observed in adult zebra fi sh models of epilepsy