Hepatitis B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a/miR-16-1 in hepatocytes

Abstract

Background: Hepatitis B virus (HBV) infection has been linked to the development of hepatocellular carcinoma (HCC) in humans. Results: Specific microRNAs inhibit HBV replication, and HBV infection also reprograms microRNA expression. Conclusion: The viral HBxRNAdirectly mediates the down-regulation of the tumor suppressor microRNA miR-15a/miR-16-1. Significance: The functional interplay between HBV infection and microRNA may contribute to HCC development. © 2013 by The American Society.