Measurement of creatinine in human plasma using a functional porous polymer structure sensing motif

11Citations
Citations of this article
30Readers
Mendeley users who have this article in their library.

Abstract

In this study, a new method for detecting creatinine was developed. This novel sensor comprised of two ionic liquids, poly-lactic-co-glycolic acid (PLGA) and 1-butyl-3methylimidazolium (BMIM) chloride, in the presence of 2′,7′-dichlorofluorescein diacetate (DCFH-DA). PLGA and BMIM chloride formed a functional porous polymer structure (FPPS)like structure. Creatinine within the FPPS rapidly hydrolyzed and released OH-, which in turn converted DCFH-DA to DCFH, developing an intense green color or green fluorescence. The conversion of DCFH to DCF+ resulted in swelling of FPPS and increased solubility. This DCF+based sensor could detect creatinine levels with detection limit of 5 µM and also measure the creatinine in blood. This novel method could be used in diagnostic applications for monitoring individuals with renal dysfunction.

Author supplied keywords

Cite

CITATION STYLE

APA

Nanda, S. S., An, S. S. A., & Yi, D. K. (2015). Measurement of creatinine in human plasma using a functional porous polymer structure sensing motif. International Journal of Nanomedicine, 10, 93–99. https://doi.org/10.2147/IJN.S88378

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free