Current status and biomedical application spectrum of poly (3-hydroxybutyrate) as a bacterial biodegradable polymer

Abstract

The biodegradable poly(3-hydroxybutyrate) (PHB) as member of natural polymer family has been widely used and advanced in the innovative biomedical areas owing to relevant combination of biocompatibility, transport characteristics, and mechanical behavior. This review presents an extensive description to hydrolysis and enzymatic degradation during long-time period preferably under laboratory condition (in vitro) and as medical implant (in vivo). Besides, the focus of review is devoted to the literature comparison of different works in PHB degradation and its biomedical application including work of authors.