Antimicrobial activity of phytochemicals extracted from Acanthus ilicifolius leaves against staphylococcus aureus: An in silico Approach

Abstract

Acanthus ilicifolius is lesser-known medicinal plant is used as medicine in traditional systems. Staphylococcus aureus is inducing many infections and it can infect tissues when the skin and mucosal barriers. The plant Acanthus ilicifolius GC-MS have reported the following phytochemicals, 26.27-Di (nor)-cholest-5, 7, 23-trien-22-ol, 3-methoxymethoxy, 9H-purin-6-amine, N, 9-bis (trimethylsilyl)-8-((trimethylsilyl) Oxy), Cyano colchicines and 3beta-methoxy-5-choleston-19-oic acid against a 12 essential protein and synthetic drug of S. aureus was collected through literature survey. S. aureus was studied zone of inhibition in different concentrations against microorganisms and essential proteins were used as target which were docked using phytochemicals (ligands) found in A. ilicifolius leaves. In the present study, to analyze the effect of A. ilicifolius against S. aureus through docking and inhibition studies, that A. ilicifolius has significant activity against S. aureus. This research was helpful attempt to the drug discovery in S. aureus. © 2013 Academic Journals Inc.