Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus

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Abstract

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.

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van der Linden, J. W. M., Arendrup, M. C., Warris, A., Lagrou, K., Pelloux, H., Hauser, P. M., … Verweij, P. E. (2015). Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus. Emerging Infectious Diseases, 21(6), 1041–1044. https://doi.org/10.3201/eid2106.140717

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