Vitreous biochemistry and artificial vitreous

Abstract

Aging of vitreous involves a degenerative process where glycosaminoglycans (GAGs) dissociate from collagen and the gel disintegrates into fluid adjacent to which collagen fibrils adhere to each other and cross-link [1–4]. In most eyes this process is accompanied by dehiscence at the vitreoretinal interface progressing to posterior vitreous detachment and nothing more happens Vitreous aging and posterior vitreous detachment]. In several pathologic conditions, vitreous is hazy due to hemorrhage and/or cell proliferation forming membranes that contract, leading to traction retinal detachment