We describe here a method for detecting the translocation of individual DNA molecules through nanopores created in graphene membranes. The devices consist of 1-5-nm thick graphene membranes with electron-beam sculpted nanopores from 5 to 10 nm in diameter. Due to the thin nature of the graphene membranes, and the reduced electrical resistance, we observe larger blocked currents than for traditional solid-state nanopores. We also show how ionic current noise levels can be reduced with the atomic-layer deposition of a few nanometers of titanium dioxide over the graphene surface. Unlike traditional solid-state nanopore materials that are insulating, graphene is an excellent electrical conductor, and its use opens the door to a new future class of nanopore devices in which electronic sensing and control is performed directly at the pore. © 2012 Springer Science+Business Media, LLC.
CITATION STYLE
Merchant, C. A., & Drndić, M. (2012). Graphene nanopore devices for DNA sensing. Methods in Molecular Biology, 870, 211–226. https://doi.org/10.1007/978-1-61779-773-6_12
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