Shortening Analysis Time (Fast GC)

Abstract

This chapter deals with the use of fast gas chromatography (GC) using narrow-bore columns. The influence of column parameters in order to shorten the analysis time is discussed from a practical point of view. While reducing analysis time, influences on sample capacity are discussed. As a conclusion, the definition of ‘typical’ column parameters is mentioned. We concluded that using narrow-bore columns with diameters between 0.1 and 0.15 mm is a very effective way of decreasing GC run times while maintaining a high degree of peak resolution compared with analysis using capillary columns of standard dimensions (inner diameter 0.25 mm and larger).The reduction of inner diameter results in several instrument requirements. Individual parameters like head pressure, column heating rates and detector requirements are discussed. As peak widths become considerably smaller compared with standard analysis, GC detectors must be able to follow rapid signal changes. The influence of sampling frequency and filter time constant as independent parameters are discussed.