Maytenus senegalensis (Lam.) Excell (Celastraceae) root extracts were investigated for their topical anti-inflammatory properties by measuring the inhibition of the Croton oil-induced ear oedema in mice. The highest anti-inflammatory activity was detected in the chloroform extract, which reduced the oedematous response with a potency similar to that of the NSAID reference drug indomethacin (ID50=84 and 93μg/cm2, respectively). Fractionation of the chloroform and of the hexane extracts led to the isolation of maytenoic acid (1), which exhibited a dose-dependent antiphlogistic effect (ID50=0.11μmol/cm2) twice that of indomethacin (ID50=0.26μmol/cm2) and only three times lower than that of hydrocortisone (ID50=0.04μmol/cm2).
CITATION STYLE
Amino Acids, Peptides, Proteins. (2008). In Food Chemistry (pp. 8–92). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-69934-7_2
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